AGR3

Across TCGA patient cohorts, AGR3 protein abundance is significantly associated with the RNA expression of many other genes, with 17,267 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible AGR3-associated genes across cancer lineages are AGR2, TSPAN1, and TPX2. Each is linked with AGR3 in more than 7 cancer types. Because this analysis shows association rather than direction, both AGR3-to-partner and partner-to-AGR3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AGR3 versus AGR2 in BRCA, with a Pearson correlation of 0.71.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGR3→partner) and Y-score (partner→AGR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AGR2 →	+4.426	+1.381	<.001	<.001	3	8
BRCA	TSPAN1 →	+2.820	+1.182	<.001	<.001	3	7
OV	TPX2 →	-1.188	-1.284	<.001	<.001	3	7
UCEC	NCAPG →	-1.032	-1.226	<.001	<.001	3	6
LSCC	FBXO5 →	-0.740	-0.604	<.001	.002	3	6
BRCA	MLPH →	+2.973	+1.162	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,267 associations by consensus.

AGR3 vs AGR2 — BRCA

Explore this scatter interactively →