AGR2

Across TCGA patient cohorts, AGR2 protein abundance is significantly associated with the RNA expression of many other genes, with 17,411 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible AGR2-associated genes across cancer lineages are TFF3, TFF1, and MLPH. Each is linked with AGR2 in more than 7 cancer types. Because this analysis shows association rather than direction, both AGR2-to-partner and partner-to-AGR2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AGR2 versus TFF3 in BRCA, with a Pearson correlation of 0.75.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGR2→partner) and Y-score (partner→AGR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TFF3 →	+4.849	+1.564	<.001	<.001	3	8
BRCA	TFF1 →	+5.463	+1.428	<.001	<.001	3	8
BRCA	MLPH →	+2.668	+1.171	<.001	<.001	3	7
BRCA	SPDEF →	+2.743	+1.245	<.001	<.001	3	7
HNSC	ZG16B →	+2.184	+0.750	<.001	<.001	3	7
BRCA	AGR3 →	+3.880	+1.541	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,411 associations by consensus.

AGR2 vs TFF3 — BRCA

Explore this scatter interactively →