AGR2

Across TCGA cell cohorts, AGR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,209 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible AGR2-associated GO terms across cancer lineages are Mucus secretion, Response to alcohol, and Positive regulation of endoplasmic reticulum unfolded protein response. Each is linked with AGR2 in more than 11 cancer types. Because this analysis shows association rather than direction, both AGR2-to-partner and partner-to-AGR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mucus secretion grouped by AGR2-low versus AGR2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AGR2→partner) and Y-score (partner→AGR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Mucus secretion →	+1.237	+4.419	<.001	<.001	3	12
OVARY	Response to alcohol →	+0.059	+2.552	<.001	<.001	3	11
URINARY_TRACT	Positive regulation of endoplasmic reticulum unfolded protein response →	+0.098	+4.790	<.001	<.001	3	11
OESOPHAGUS	Secretion by tissue →	+0.445	+7.110	<.001	<.001	3	11
URINARY_TRACT	Positive regulation of sodium ion transport →	+0.211	+4.683	<.001	<.001	3	10
OESOPHAGUS	Regulation of hippocampal neuron apoptotic process →	+1.144	+3.882	.004	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,209 associations by consensus.

Mucus secretion by AGR2 expression — LUNG_SCLC

Explore this box plot interactively →