AGPAT5

Across TCGA pan-cancer cohorts, AGPAT5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated AGPAT5 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher AGPAT5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated AGPAT5 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, PDAC, and LUAD are the cancer types where AGPAT5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	1.000	0.886	.023	36	view →
PDAC	OS	Quartile	II,III,IV	0.704	0.450	.018	8	view →
LUAD	DFS	Tertile	III,IV	0.993	0.471	.035	5	view →
GBM	OS	Median	All	0.487	0.282	.024	4	view →
HNSC	DFS	Median	III,IV	0.913	0.992	.048	1	view →
LSCC	DFS	Tertile	II,III,IV	0.525	1.000	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

AGPAT5–COAD (DFS)

Open the COAD breakdown →