AGPAT5

Across TCGA patient cohorts, AGPAT5 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGPAT5-associated genes across cancer lineages are Annexin-1, ATM, and Caspase-7-cleavedD198. Each is linked with AGPAT5 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGPAT5-to-partner and partner-to-AGPAT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by AGPAT5-low versus AGPAT5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGPAT5→partner) and Y-score (partner→AGPAT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.575	+3.584	.003	.002	3	2
UCEC	ATM →	-0.351	-1.765	.039	.014	3	2
UCEC	Caspase-7-cleavedD198 →	+0.796	+2.169	<.001	.003	3	2
UCEC	c-Myc →	-0.189	-1.401	.040	.046	3	2
UCEC	eIF4E →	+0.179	+3.013	.023	.018	3	1
UCEC	ERK2 →	+0.176	+2.321	.015	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Annexin-1 by AGPAT5 expression — UCEC

Explore this box plot interactively →