AGPAT3

Across TCGA patient cohorts, AGPAT3 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGPAT3-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and eIF4G. Each is linked with AGPAT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGPAT3-to-partner and partner-to-AGPAT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by AGPAT3-low versus AGPAT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGPAT3→partner) and Y-score (partner→AGPAT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.086	-1.780	.009	.024	3	1
UCEC	eIF4E →	+0.213	+3.713	.002	<.001	3	1
UCEC	eIF4G →	+0.266	+3.700	.009	.001	3	1
UCEC	ACC_pS79 →	+0.297	+2.115	.009	.016	3	1
UCEC	ACC1 →	+0.309	+1.750	.009	.049	3	1
UCEC	ACVRL1 →	-0.097	-1.986	.031	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

14-3-3_beta by AGPAT3 expression — UCEC

Explore this box plot interactively →