AGO4

Across TCGA patient cohorts, AGO4 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,207 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible AGO4-associated proteins across cancer lineages are RRBP1, SRP68, and EIF2S2. Each is linked with AGO4 in more than 5 cancer types. Because this analysis shows association rather than direction, both AGO4-to-partner and partner-to-AGO4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AGO4 versus RRBP1 in LSCC, with a Pearson correlation of -0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AGO4→partner) and Y-score (partner→AGO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RRBP1 →	-0.444	-0.467	<.001	<.001	3	6
BRCA	SRP68 →	-0.310	-0.461	<.001	<.001	3	5
HNSC	EIF2S2 →	-0.183	-0.541	.002	<.001	3	5
LSCC	TRRAP →	+0.216	+0.316	<.001	.002	3	4
LUAD	RPL3 →	-0.446	-0.401	<.001	<.001	3	4
HNSC	RPL5 →	-0.179	-0.412	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,207 associations by consensus.

AGO4 vs RRBP1 — LSCC

Explore this scatter interactively →