AGO4

Across TCGA patient cohorts, AGO4 protein abundance is significantly associated with the RNA expression of many other genes, with 1,473 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible AGO4-associated genes across cancer lineages are DUT, FOXD2, and ST20-AS1. Each is linked with AGO4 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGO4-to-partner and partner-to-AGO4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AGO4 versus DUT in BRCA, with a Pearson correlation of 0.27.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGO4→partner) and Y-score (partner→AGO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DUT →	+0.450	+0.292	<.001	.001	3	2
BRCA	FOXD2 →	+0.572	+0.317	.005	.002	3	2
LUAD	ST20-AS1 →	+0.184	+0.119	.005	.009	3	2
LSCC	CSF3R →	+1.141	+0.254	<.001	<.001	3	2
UCEC	FGF2 →	+0.596	+0.224	.005	.001	3	2
UCEC	GUCY1A2 →	+1.302	+0.263	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,473 associations by consensus.

AGO4 vs DUT — BRCA

Explore this scatter interactively →