AGO4

Across TCGA patient cohorts, AGO4 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGO4-associated genes across cancer lineages are cIAP, eEF2, and MEK1. Each is linked with AGO4 in more than 2 cancer types. Because this analysis shows association rather than direction, both AGO4-to-partner and partner-to-AGO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, cIAP grouped by AGO4-low versus AGO4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGO4→partner) and Y-score (partner→AGO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	cIAP →	+0.171	+2.820	.009	.035	3	3
UCEC	eEF2 →	+0.311	+1.584	.006	.032	3	3
UCEC	MEK1 →	+0.384	+2.058	<.001	<.001	3	2
COAD	ATM →	-0.479	-2.991	.018	.036	2	3
UCEC	ERK2 →	+0.184	+1.584	.002	.017	3	2
UCEC	FoxM1 →	+0.228	+2.058	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

cIAP by AGO4 expression — COAD

Explore this box plot interactively →