AGO4

Across TCGA cell cohorts, AGO4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,975 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AGO4-associated GO terms across cancer lineages are Pre-miRNA processing, Vacuolar transport, and Regulation of cell cycle G1/S phase transition. Each is linked with AGO4 in more than 15 cancer types. Because this analysis shows association rather than direction, both AGO4-to-partner and partner-to-AGO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pre-miRNA processing grouped by AGO4-low versus AGO4-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AGO4→partner) and Y-score (partner→AGO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Pre-miRNA processing →	+0.165	+1.750	<.001	<.001	3	16
OVARY	Vacuolar transport →	+0.060	+0.903	<.001	<.001	3	14
BREAST	Regulation of cell cycle G1/S phase transition →	+0.080	+0.997	<.001	<.001	3	14
STOMACH	Cell division →	+0.088	+1.376	<.001	<.001	3	14
LUNG_SCLC	RISC complex assembly →	+0.122	+0.723	<.001	<.001	3	14
STOMACH	Vesicle-mediated transport to the plasma membrane →	+0.054	+1.014	<.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,975 associations by consensus.

Pre-miRNA processing by AGO4 expression — STOMACH

Explore this box plot interactively →