AGO4

Across TCGA cell cohorts, AGO4 mutation is significantly associated with the RNA expression of many other genes, with 448 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AGO4-associated genes across cancer lineages are KDELR3, CBY1, and MIOX. Each is linked with AGO4 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGO4-to-partner and partner-to-AGO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KDELR3 grouped by AGO4-low versus AGO4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGO4→partner) and Y-score (partner→AGO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KDELR3 →	+1.612	+3.212	<.001	.006	3	1
LARGE_INTESTINE	CBY1 →	+0.749	+3.160	<.001	.006	3	1
LARGE_INTESTINE	MIOX →	+0.317	+3.212	<.001	.006	3	1
LARGE_INTESTINE	ADNP2 →	+0.847	+3.212	<.001	.006	3	1
LARGE_INTESTINE	RBFA →	+0.738	+3.212	.004	.006	3	1
LARGE_INTESTINE	CLUAP1 →	+0.681	+3.385	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 448 associations by consensus.

KDELR3 by AGO4 expression — LARGE_INTESTINE

Explore this box plot interactively →