AGO1

Across TCGA patient cohorts, AGO1 protein abundance is significantly associated with the RNA expression of many other genes, with 17,958 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible AGO1-associated genes across cancer lineages are ZDHHC15, JAM2, and ZNF540. Each is linked with AGO1 in more than 8 cancer types. Because this analysis shows association rather than direction, both AGO1-to-partner and partner-to-AGO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AGO1 versus ZDHHC15 in CCRCC, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGO1→partner) and Y-score (partner→AGO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ZDHHC15 →	+0.591	+0.202	<.001	<.001	3	9
UCEC	JAM2 →	+0.862	+0.287	<.001	<.001	3	9
BRCA	ZNF540 →	+0.782	+0.238	<.001	<.001	3	9
CCRCC	SULT1C4 →	+1.430	+0.155	.001	.006	3	9
GBM	MAGEE2 →	+0.588	+0.198	<.001	<.001	3	8
BRCA	CBX7 →	+0.694	+0.218	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,958 associations by consensus.

AGO1 vs ZDHHC15 — CCRCC

Explore this scatter interactively →