AGO1

Across TCGA patient cohorts, AGO1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGO1-associated genes across cancer lineages are ACC1, eIF4E, and JNK2. Each is linked with AGO1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AGO1-to-partner and partner-to-AGO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by AGO1-low versus AGO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGO1→partner) and Y-score (partner→AGO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.346	+1.820	.003	.014	3	3
UCEC	eIF4E →	+0.192	+1.392	.005	.019	3	2
UCEC	JNK2 →	+0.161	+2.009	.014	.005	3	2
UCEC	MEK1 →	+0.502	+2.643	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.476	+1.906	.006	.014	3	2
UCEC	Shc_pY317 →	-0.155	-1.392	.001	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ACC1 by AGO1 expression — UCEC

Explore this box plot interactively →