AGO1

Across TCGA cell cohorts, AGO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,641 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AGO1-associated GO terms across cancer lineages are RISC complex assembly, Pre-miRNA processing, and Regulation of mRNA catabolic process. Each is linked with AGO1 in more than 19 cancer types. Because this analysis shows association rather than direction, both AGO1-to-partner and partner-to-AGO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RISC complex assembly grouped by AGO1-low versus AGO1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AGO1→partner) and Y-score (partner→AGO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RISC complex assembly →	+0.168	+1.754	<.001	<.001	3	20
STOMACH	Pre-miRNA processing →	+0.149	+1.584	<.001	<.001	3	19
BONE	Regulation of mRNA catabolic process →	+0.054	+1.016	<.001	<.001	3	18
BONE	mRNA alternative polyadenylation →	+0.103	+0.870	.001	.001	2	18
KIDNEY	Peptidyl-serine phosphorylation →	+0.085	+0.761	.001	.003	3	17
STOMACH	Peptidyl-serine modification →	+0.087	+1.243	.007	.004	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,641 associations by consensus.

RISC complex assembly by AGO1 expression — STOMACH

Explore this box plot interactively →