AGMAT

Across TCGA patient cohorts, AGMAT mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGMAT-associated genes across cancer lineages are A-Raf_pS299, FOXO3a_pS318_S321, and PDCD4. Each is linked with AGMAT in more than 1 cancer types. Because this analysis shows association rather than direction, both AGMAT-to-partner and partner-to-AGMAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by AGMAT-low versus AGMAT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGMAT→partner) and Y-score (partner→AGMAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.243	-3.459	<.001	.005	3	1
UCEC	FOXO3a_pS318_S321 →	-0.206	-3.459	<.001	.005	3	1
UCEC	PDCD4 →	-0.560	-2.321	.017	.035	3	1
UCEC	beta-Catenin →	+0.522	+2.321	.040	.035	3	1
UCEC	Di-Ras3 →	-0.189	-2.321	.011	.035	3	1
UCEC	Dvl3 →	+0.290	+2.321	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

A-Raf_pS299 by AGMAT expression — UCEC

Explore this box plot interactively →