AGL

Across TCGA pan-cancer cohorts, AGL mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated AGL data layer compared with 24 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher AGL mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated AGL expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LSCC, OV, and HNSC are the cancer types where AGL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	III,IV	0.990	0.569	.006	20	view →
OV	DFS	Quartile	All	0.593	1.000	.034	4	view →
HNSC	DFS	Quartile	II,III,IV	0.887	1.000	.011	4	view →
UCEC	DFS	Quartile	All	0.966	0.783	.031	4	view →
CCRCC	DFS	Median	III,IV	0.818	0.244	.031	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

AGL–LSCC (DFS)

Open the LSCC breakdown →