AGL

Across TCGA patient cohorts, AGL mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGL-associated genes across cancer lineages are FoxM1, TFRC, and C-Raf. Each is linked with AGL in more than 3 cancer types. Because this analysis shows association rather than direction, both AGL-to-partner and partner-to-AGL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by AGL-low versus AGL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGL→partner) and Y-score (partner→AGL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.189	+1.893	.018	<.001	3	4
UCEC	TFRC →	+0.511	+1.643	.001	.003	3	4
UCEC	C-Raf →	+0.140	+1.362	.001	.034	3	4
UCEC	Cyclin-B1 →	+0.651	+2.662	<.001	<.001	3	3
UCEC	Cyclin-E2 →	+0.132	+1.643	.011	.003	3	3
LUAD	RAD51 →	+0.205	+2.186	.022	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

FoxM1 by AGL expression — UCEC

Explore this box plot interactively →