AGL

Across TCGA cell cohorts, AGL RNA expression is significantly associated with the go_rna of many other GO terms, with 3,922 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AGL-associated GO terms across cancer lineages are Chromosomal 5-methylcytosine DNA demethylation pathway, Positive regulation of centriole replication, and Epigenetic regulation of gene expression. Each is linked with AGL in more than 13 cancer types. Because this analysis shows association rather than direction, both AGL-to-partner and partner-to-AGL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chromosomal 5-methylcytosine DNA demethylation pathway grouped by AGL-low versus AGL-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AGL→partner) and Y-score (partner→AGL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Chromosomal 5-methylcytosine DNA demethylation pathway →	+0.175	+0.965	<.001	<.001	3	14
BLOOD_Myeloma	Positive regulation of centriole replication →	+0.120	+1.007	.003	.001	2	14
OVARY	Epigenetic regulation of gene expression →	+0.061	+0.831	<.001	<.001	3	12
BLOOD_Leukemia	Copper ion export →	-0.172	-0.544	<.001	.003	3	12
LUNG_SCLC	Regulation of centriole replication →	+0.102	+0.772	<.001	<.001	3	12
LIVER	Regulation of nucleobase-containing compound transport →	+0.165	+0.945	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,922 associations by consensus.

Chromosomal 5-methylcytosine DNA demethylation pathway by AGL expression — LARGE_INTESTINE

Explore this box plot interactively →