AGGF1

Across TCGA cell cohorts, AGGF1 mutation is significantly associated with the RNA expression of many other genes, with 520 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AGGF1-associated genes across cancer lineages are PRM2, MAGEB10, and PRAMEF8. Each is linked with AGGF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGGF1-to-partner and partner-to-AGGF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRM2 grouped by AGGF1-low versus AGGF1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGGF1→partner) and Y-score (partner→AGGF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PRM2 →	+0.035	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	MAGEB10 →	+0.021	+4.544	.002	.003	3	1
LUNG_NSCLC_LUAD	PRAMEF8 →	+0.015	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	PRAMEF19 →	+0.012	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	KRTAP10-7 →	+0.011	+4.662	<.001	.005	3	1
CNS	GFRA4 →	+0.022	+5.754	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 520 associations by consensus.

PRM2 by AGGF1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →