AGFG2

Across TCGA patient cohorts, AGFG2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGFG2-associated genes across cancer lineages are GAPDH, Notch1, and ATM. Each is linked with AGFG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGFG2-to-partner and partner-to-AGFG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by AGFG2-low versus AGFG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGFG2→partner) and Y-score (partner→AGFG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.485	+1.678	.018	.023	3	2
UCEC	Notch1 →	+0.115	+2.469	.033	.010	3	2
UCEC	ATM →	-0.557	-2.222	.001	.010	3	2
SKCM	Chk1_pS345 →	+0.166	+3.000	.029	.036	3	1
UCEC	ERK2 →	+0.263	+2.115	<.001	.017	3	1
UCEC	p62 Lck ligand →	+0.277	+2.321	.026	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

GAPDH by AGFG2 expression — UCEC

Explore this box plot interactively →