Across TCGA patient cohorts, AGER mutation is significantly associated with the RNA expression of many other genes, with 1,102 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGER-associated genes across cancer lineages are GPR6, LINC01072, and ELAVL4-AS1. Each is linked with AGER in more than 1 cancer types. Because this analysis shows association rather than direction, both AGER-to-partner and partner-to-AGER results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGER→partner) and Y-score (partner→AGER) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	GPR6 →	+0.029	+5.008	<.001	.004	3	2
UCEC	LINC01072 →	+0.117	+2.488	.001	.001	3	2
SKCM	ELAVL4-AS1 →	+0.230	+4.855	.001	<.001	3	2
UCEC	KIR3DL1 →	+0.196	+4.367	.001	<.001	3	2
CESC	RNU1-62P →	+0.312	+5.539	<.001	.004	3	2
CESC	RNU1-17P →	+0.378	+5.103	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,102 associations by consensus.

Exploration

AGER survival (RNA) · tumor vs normal (RNA) · all AGER data types