Across TCGA patient cohorts, AGER mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGER-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and Gab2. Each is linked with AGER in more than 1 cancer types. Because this analysis shows association rather than direction, both AGER-to-partner and partner-to-AGER results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGER→partner) and Y-score (partner→AGER) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.182	+2.820	.048	.035	3	2
UCEC	A-Raf_pS299 →	-0.162	-3.321	.001	.010	3	1
UCEC	Gab2 →	+0.352	+2.115	.024	.019	3	1
UCEC	Notch1 →	+0.165	+2.115	.007	.019	3	1
UCEC	p62 Lck ligand →	+0.321	+2.594	.024	.006	3	1
UCEC	Annexin-1 →	+0.804	+3.604	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

AGER survival (RNA) · tumor vs normal (RNA) · all AGER data types