AGBL5

Across TCGA patient cohorts, AGBL5 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGBL5-associated genes across cancer lineages are CD49b, FoxM1, and Notch1. Each is linked with AGBL5 in more than 2 cancer types. Because this analysis shows association rather than direction, both AGBL5-to-partner and partner-to-AGBL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD49b grouped by AGBL5-low versus AGBL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGBL5→partner) and Y-score (partner→AGBL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD49b →	-0.215	-2.067	.012	.005	3	3
UCEC	FoxM1 →	+0.185	+1.321	.018	.012	3	2
UCEC	Notch1 →	+0.165	+2.009	<.001	.001	3	2
UCEC	PCNA →	+0.194	+1.999	.002	<.001	3	2
UCEC	PR →	-0.183	-1.925	.015	.004	3	2
UCEC	AMPK_pT172 →	+0.278	+1.138	.025	.022	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

CD49b by AGBL5 expression — UCEC

Explore this box plot interactively →