Across TCGA patient cohorts, AGBL4 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGBL4-associated genes across cancer lineages are p38-MAPK_pT180_Y182, 4E-BP1_pT37_T46, and 14-3-3_beta. Each is linked with AGBL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGBL4-to-partner and partner-to-AGBL4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGBL4→partner) and Y-score (partner→AGBL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.440	-1.764	.002	.002	3	2
UCEC	4E-BP1_pT37_T46 →	-0.308	-1.893	.010	.014	3	2
UCEC	14-3-3_beta →	-0.075	-1.780	.018	.024	3	1
UCEC	eEF2 →	+0.312	+2.321	.006	.005	3	1
UCEC	EGFR_pY1068 →	-0.198	-1.847	.013	.007	3	1
UCEC	A-Raf_pS299 →	-0.105	-2.115	.006	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Exploration

AGBL4 survival (RNA) · tumor vs normal (RNA) · all AGBL4 data types