Across TCGA pan-cancer cohorts, AGBL4-IT1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of AGBL4-IT1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where AGBL4-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types AGBL4-IT1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.
KICH and BRCA are the cancer types where AGBL4-IT1 tumor–normal differential expression is most reproducible.