AGBL3

Across TCGA patient cohorts, AGBL3 mutation is significantly associated with the RNA expression of many other genes, with 1,132 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGBL3-associated genes across cancer lineages are C9orf50, TMIE, and HCAR1. Each is linked with AGBL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGBL3-to-partner and partner-to-AGBL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf50 grouped by AGBL3-low versus AGBL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGBL3→partner) and Y-score (partner→AGBL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C9orf50 →	-0.383	-3.087	.004	<.001	3	2
UCEC	TMIE →	-0.454	-1.574	.004	.005	3	2
UCEC	HCAR1 →	-0.438	-2.574	.002	<.001	3	2
UCEC	LINC01072 →	+0.126	+2.556	<.001	<.001	3	2
UCEC	SLC25A17 →	+0.271	+1.879	.009	.004	3	2
UCEC	KCTD9 →	+0.602	+3.269	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,132 associations by consensus.

C9orf50 by AGBL3 expression — UCEC

Explore this box plot interactively →