AGBL3

Across TCGA patient cohorts, AGBL3 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGBL3-associated genes across cancer lineages are S6_pS240_S244, ATM, and 4E-BP1. Each is linked with AGBL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGBL3-to-partner and partner-to-AGBL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by AGBL3-low versus AGBL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGBL3→partner) and Y-score (partner→AGBL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.298	+2.335	.034	.018	3	2
UCEC	ATM →	-0.343	-1.440	.029	.024	3	2
UCEC	4E-BP1 →	+0.214	+3.169	.023	.018	3	2
UCEC	14-3-3_beta →	-0.076	-3.432	.029	.005	3	1
UCEC	ERK2 →	+0.170	+2.321	.010	.005	3	1
UCEC	Fibronectin →	-0.317	-2.492	.005	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

S6_pS240_S244 by AGBL3 expression — UCEC

Explore this box plot interactively →