AGBL2

Across TCGA pan-cancer cohorts, AGBL2 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated AGBL2 data layer compared with 20 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher AGBL2 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated AGBL2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, SCLC, and ESCA are the cancer types where AGBL2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.960	0.625	.012	34	view →
SCLC	OS	Median	All	0.178	0.714	<.001	18	view →
ESCA	DFS	Median	II,III,IV	0.089	0.522	.001	12	view →
BLCA	DFS	Median	All	0.078	0.594	<.001	9	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

AGBL2–UCEC (DFS)

Open the UCEC breakdown →