AGBL2

Across TCGA patient cohorts, AGBL2 mutation is significantly associated with the RNA expression of many other genes, with 3,168 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGBL2-associated genes across cancer lineages are PKN3, LRR1, and ATF7IP2. Each is linked with AGBL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both AGBL2-to-partner and partner-to-AGBL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKN3 grouped by AGBL2-low versus AGBL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGBL2→partner) and Y-score (partner→AGBL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKN3 →	+0.795	+2.273	<.001	<.001	3	3
UCEC	LRR1 →	+0.640	+2.263	<.001	<.001	3	3
UCEC	ATF7IP2 →	-0.765	-1.989	<.001	.008	3	3
UCEC	NUDCD2 →	+0.410	+2.284	.002	<.001	3	3
UCEC	DTWD1 →	+0.382	+1.684	<.001	.003	3	3
UCEC	SNHG30 →	+0.538	+2.284	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,168 associations by consensus.

PKN3 by AGBL2 expression — UCEC

Explore this box plot interactively →