AGBL2

Across TCGA patient cohorts, AGBL2 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGBL2-associated genes across cancer lineages are C-Raf, Ku80, and ASNS. Each is linked with AGBL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both AGBL2-to-partner and partner-to-AGBL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by AGBL2-low versus AGBL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGBL2→partner) and Y-score (partner→AGBL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.117	+1.584	.020	.034	3	3
UCEC	Ku80 →	+0.240	+1.375	.003	.024	3	2
UCEC	ASNS →	+0.533	+1.662	<.001	.011	3	2
UCEC	Caspase-8 →	-0.267	-4.060	.002	<.001	3	2
UCEC	EGFR_pY1068 →	-0.185	-1.362	.037	.037	3	1
UCEC	eIF4G →	+0.353	+3.584	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

C-Raf by AGBL2 expression — UCEC

Explore this box plot interactively →