AGBL2

Across TCGA cell cohorts, AGBL2 mutation is significantly associated with the RNA expression of many other genes, with 55 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible AGBL2-associated genes across cancer lineages are TBATA, OR2M3, and OR8B4. Each is linked with AGBL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGBL2-to-partner and partner-to-AGBL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBATA grouped by AGBL2-low versus AGBL2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGBL2→partner) and Y-score (partner→AGBL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TBATA →	+0.252	+4.544	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	OR2M3 →	+0.157	+4.357	<.001	.006	3	2
UPPER_AERODIGESTIVE_TRACT	OR8B4 →	+0.027	+4.357	<.001	.006	3	2
LUNG_SCLC	F9 →	+0.022	+4.058	<.001	.007	3	1
LUNG_SCLC	AICDA →	+0.065	+3.898	<.001	.005	3	1
LUNG_SCLC	IL36A →	+0.016	+4.058	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

TBATA by AGBL2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →