AGAP7P

Across TCGA patient cohorts, AGAP7P mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGAP7P-associated genes across cancer lineages are EGFR_pY1068, mTOR_pS2448, and ERK2. Each is linked with AGAP7P in more than 1 cancer types. Because this analysis shows association rather than direction, both AGAP7P-to-partner and partner-to-AGAP7P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by AGAP7P-low versus AGAP7P-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGAP7P→partner) and Y-score (partner→AGAP7P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.246	-2.321	.017	.006	3	2
UCEC	mTOR_pS2448 →	-0.145	-1.807	.018	.027	3	2
UCEC	ERK2 →	+0.230	+2.321	.003	.033	3	1
UCEC	MSH2 →	-0.335	-1.807	<.001	.027	3	1
UCEC	MSH6 →	-0.461	-3.584	<.001	.002	3	1
UCEC	p62 Lck ligand →	+0.320	+2.179	.017	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

EGFR_pY1068 by AGAP7P expression — UCEC

Explore this box plot interactively →