Across TCGA patient cohorts, AGAP6 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGAP6-associated genes across cancer lineages are Caspase-7-cleavedD198, MEK1, and MSH2. Each is linked with AGAP6 in more than 2 cancer types. Because this analysis shows association rather than direction, both AGAP6-to-partner and partner-to-AGAP6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGAP6→partner) and Y-score (partner→AGAP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.848	+2.434	<.001	.001	3	3
UCEC	MEK1 →	+0.447	+3.807	<.001	<.001	3	2
UCEC	MSH2 →	-0.285	-2.295	<.001	.033	3	2
UCEC	Annexin-1 →	+0.442	+2.019	.022	.017	3	2
UCEC	14-3-3_beta →	-0.107	-3.558	.003	.002	3	1
UCEC	Ku80 →	+0.244	+1.515	.004	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

AGAP6 survival (RNA) · tumor vs normal (RNA) · all AGAP6 data types