AGAP3

Across TCGA patient cohorts, AGAP3 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGAP3-associated genes across cancer lineages are Lck, EGFR_pY1068, and Heregulin. Each is linked with AGAP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both AGAP3-to-partner and partner-to-AGAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by AGAP3-low versus AGAP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGAP3→partner) and Y-score (partner→AGAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.156	+2.321	.034	.034	3	3
COAD	EGFR_pY1068 →	-0.424	-2.987	.005	.035	3	2
COAD	Heregulin →	+0.269	+2.212	<.001	.033	3	2
COAD	PARP_cleaved →	+0.735	+3.012	.003	.018	3	2
COAD	Stathmin →	+0.180	+2.178	.012	.035	3	2
UCEC	FoxM1 →	+0.201	+1.594	.034	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Lck by AGAP3 expression — UCEC

Explore this box plot interactively →