AGAP2

Across TCGA patient cohorts, AGAP2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGAP2-associated genes across cancer lineages are FoxM1, TFRC, and ATM. Each is linked with AGAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGAP2-to-partner and partner-to-AGAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by AGAP2-low versus AGAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGAP2→partner) and Y-score (partner→AGAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.164	+1.201	.041	.028	3	2
UCEC	TFRC →	+0.356	+1.415	.030	.010	3	2
UCEC	ATM →	-0.456	-1.664	.001	.019	3	2
UCEC	CD49b →	-0.259	-2.565	.003	.001	3	2
UCEC	4E-BP1 →	+0.303	+3.807	<.001	<.001	3	2
COAD	TAZ →	+0.235	+2.832	.015	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

FoxM1 by AGAP2 expression — UCEC

Explore this box plot interactively →