AGAP2

Across TCGA cell cohorts, AGAP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,865 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AGAP2-associated GO terms across cancer lineages are mRNA alternative polyadenylation, DNA replication-dependent chromatin disassembly, and Regulation of smoothened signaling pathway. Each is linked with AGAP2 in more than 6 cancer types. Because this analysis shows association rather than direction, both AGAP2-to-partner and partner-to-AGAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA alternative polyadenylation grouped by AGAP2-low versus AGAP2-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AGAP2→partner) and Y-score (partner→AGAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	mRNA alternative polyadenylation →	+0.071	+0.747	<.001	<.001	3	7
BONE	DNA replication-dependent chromatin disassembly →	+0.130	+1.180	.006	.005	3	6
OVARY	Regulation of smoothened signaling pathway →	+0.033	+0.921	.003	.001	3	6
UPPER_AERODIGESTIVE_TRACT	Response to transition metal nanoparticle →	-0.285	-0.519	<.001	.003	3	6
BONE	Negative regulation of purine nucleotide biosynthetic process →	+0.136	+1.278	.004	.001	2	7
OVARY	Regulation of autophagosome maturation →	+0.082	+1.494	.002	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,865 associations by consensus.

mRNA alternative polyadenylation by AGAP2 expression — BLOOD_Lymphoma

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