AGAP2

Across TCGA cell cohorts, AGAP2 mutation is significantly associated with the RNA expression of many other genes, with 1,070 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AGAP2-associated genes across cancer lineages are MEI4, IL4, and OR10J1. Each is linked with AGAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGAP2-to-partner and partner-to-AGAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEI4 grouped by AGAP2-low versus AGAP2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGAP2→partner) and Y-score (partner→AGAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MEI4 →	+0.105	+4.137	<.001	.001	3	2
BONE	IL4 →	+0.226	+4.146	<.001	.002	3	2
BREAST	OR10J1 →	+0.425	+4.781	<.001	.003	3	2
LARGE_INTESTINE	ANKRD54 →	+0.556	+3.237	<.001	.003	3	2
LARGE_INTESTINE	CLUAP1 →	+0.680	+3.459	<.001	.001	3	2
LARGE_INTESTINE	NEK4 →	+0.640	+3.321	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,070 associations by consensus.

MEI4 by AGAP2 expression — OESOPHAGUS

Explore this box plot interactively →