AGA

Across TCGA pan-cancer cohorts, AGA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated AGA data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher AGA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated AGA expression acts as an unfavorable survival marker.

LUAD, GBM, and PDAC are the cancer types where AGA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.703	0.921	.010	18	view →
GBM	DFS	Quartile	All	0.276	0.576	.006	8	view →
PDAC	OS	Median	IV	0.395	0.937	.026	6	view →
CCRCC	DFS	Quartile	III,IV	0.222	0.887	.017	5	view →
OV	DFS	Median	All	0.561	1.000	.026	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

AGA–LUAD (DFS)

Open the LUAD breakdown →