AGA

Across TCGA patient cohorts, AGA mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGA-associated genes across cancer lineages are MSH2, Caspase-7-cleavedD198, and GSK3-a-b. Each is linked with AGA in more than 1 cancer types. Because this analysis shows association rather than direction, both AGA-to-partner and partner-to-AGA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by AGA-low versus AGA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGA→partner) and Y-score (partner→AGA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.294	-3.295	.002	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.540	+2.189	.031	.034	3	2
UCEC	GSK3-a-b →	-0.146	-2.321	.010	.034	3	1
UCEC	MEK1 →	+0.430	+2.906	.005	.001	3	1
UCEC	Notch1 →	+0.190	+1.750	.001	.049	3	1
UCEC	p27_pT198 →	+0.163	+3.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

MSH2 by AGA expression — UCEC

Explore this box plot interactively →