AGA

Across TCGA cell cohorts, AGA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,751 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible AGA-associated GO terms across cancer lineages are Viral translational termination-reinitiation, Endoplasmic reticulum to cytosol transport, and Regulation of endosome organization. Each is linked with AGA in more than 10 cancer types. Because this analysis shows association rather than direction, both AGA-to-partner and partner-to-AGA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Viral translational termination-reinitiation grouped by AGA-low versus AGA-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AGA→partner) and Y-score (partner→AGA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Viral translational termination-reinitiation →	+0.049	+0.567	.004	.001	3	11
OESOPHAGUS	Endoplasmic reticulum to cytosol transport →	+0.145	+1.351	<.001	<.001	3	10
SKIN	Regulation of endosome organization →	+0.114	+0.877	.004	.003	2	11
OESOPHAGUS	Retrograde protein transport, ER to cytosol →	+0.145	+1.351	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Nucleotide-sugar metabolic process →	+0.083	+0.905	.003	.008	3	9
SKIN	Protein destabilization →	+0.054	+0.751	.003	.007	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,751 associations by consensus.

Viral translational termination-reinitiation by AGA expression — SKIN

Explore this box plot interactively →