AFTPH

Across TCGA patient cohorts, AFTPH mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AFTPH-associated genes across cancer lineages are p38-MAPK_pT180_Y182, PCNA, and PDCD4. Each is linked with AFTPH in more than 1 cancer types. Because this analysis shows association rather than direction, both AFTPH-to-partner and partner-to-AFTPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by AFTPH-low versus AFTPH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFTPH→partner) and Y-score (partner→AFTPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.440	-1.986	.005	.003	3	2
UCEC	PCNA →	+0.262	+2.807	<.001	.002	3	2
UCEC	PDCD4 →	-0.572	-1.662	<.001	.011	3	2
UCEC	Src_pY527 →	-0.396	-2.459	.009	.018	3	2
UCEC	ATM →	-0.493	-1.662	.002	.011	3	2
UCEC	CDK1 →	+0.116	+1.362	.030	.037	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

p38-MAPK_pT180_Y182 by AFTPH expression — UCEC

Explore this box plot interactively →