AFTPH

Across TCGA cell cohorts, AFTPH RNA expression is significantly associated with the go_rna of many other GO terms, with 3,324 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AFTPH-associated GO terms across cancer lineages are Regulation of translation initiation in response to endoplasmic reticulum stress, Insulin-like growth factor receptor signaling pathway, and Membrane fission. Each is linked with AFTPH in more than 9 cancer types. Because this analysis shows association rather than direction, both AFTPH-to-partner and partner-to-AFTPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of translation initiation in response to endoplasmic reticulum stress grouped by AFTPH-low versus AFTPH-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AFTPH→partner) and Y-score (partner→AFTPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of translation initiation in response to endoplasmic reticulum stress →	+0.142	+0.754	<.001	.002	3	10
PANCREAS	Insulin-like growth factor receptor signaling pathway →	+0.088	+0.493	<.001	<.001	3	10
LUNG_SCLC	Membrane fission →	+0.068	+0.687	.002	.001	3	10
LUNG_SCLC	Carbohydrate biosynthetic process →	-0.117	-0.939	<.001	<.001	3	10
LUNG_SCLC	Golgi to vacuole transport →	+0.104	+0.487	<.001	.001	3	9
BREAST	Actin filament-based transport →	+0.131	+0.618	.002	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,324 associations by consensus.

Regulation of translation initiation in response to endoplasmic reticulum stress by AFTPH expression — URINARY_TRACT

Explore this box plot interactively →