AFTPH

Across TCGA cell cohorts, AFTPH mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible AFTPH-associated genes across cancer lineages are CFHR2, OR1M1, and FOXI2. Each is linked with AFTPH in more than 1 cancer types. Because this analysis shows association rather than direction, both AFTPH-to-partner and partner-to-AFTPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR2 grouped by AFTPH-low versus AFTPH-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFTPH→partner) and Y-score (partner→AFTPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CFHR2 →	+0.032	+3.700	<.001	.009	3	2
SOFT_TISSUE	OR1M1 →	+0.044	+4.930	<.001	.008	3	1
STOMACH	FOXI2 →	+0.016	+5.285	<.001	.003	3	1
OVARY	SSTR4 →	+0.029	+5.196	<.001	.005	3	1
OVARY	OR5AN1 →	+0.016	+5.807	<.001	.001	3	1
OVARY	CCER1 →	+0.079	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

CFHR2 by AFTPH expression — LARGE_INTESTINE

Explore this box plot interactively →