AFP

Across TCGA pan-cancer cohorts, AFP Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated AFP data layer compared with 25 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher AFP Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated AFP expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, STAD, and LUSC are the cancer types where AFP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.429	.004	36	view →
STAD	OS	Median	All	0.168	0.583	.012	27	view →
LUSC	DFS	Median	All	0.123	0.761	<.001	12	view →
CESC	DFS	Median	II,III,IV	0.146	0.705	.010	6	view →
LGG	OS	Median	All	0.353	0.812	.004	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

AFP–UCEC (DFS)

Open the UCEC breakdown →