Across TCGA patient cohorts, AFMID mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AFMID-associated genes across cancer lineages are p62 Lck ligand, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with AFMID in more than 1 cancer types. Because this analysis shows association rather than direction, both AFMID-to-partner and partner-to-AFMID results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFMID→partner) and Y-score (partner→AFMID) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.396	+2.700	<.001	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.989	+2.247	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.119	-3.558	.001	.002	3	1
UCEC	EGFR_pY1068 →	-0.220	-1.807	.017	.025	3	1
UCEC	ERK2 →	+0.195	+2.700	.005	.005	3	1
UCEC	Notch1 →	+0.134	+2.232	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

AFMID survival (RNA) · tumor vs normal (RNA) · all AFMID data types