AFG3L2

Across TCGA patient cohorts, AFG3L2 protein abundance is significantly associated with the RNA expression of many other genes, with 17,858 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AFG3L2-associated genes across cancer lineages are NCF4, ARHGDIB, and ITGA4. Each is linked with AFG3L2 in more than 6 cancer types. Because this analysis shows association rather than direction, both AFG3L2-to-partner and partner-to-AFG3L2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AFG3L2 versus NCF4 in UCEC, with a Pearson correlation of -0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFG3L2→partner) and Y-score (partner→AFG3L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCF4 →	-0.823	-0.380	<.001	.002	3	7
OV	ARHGDIB →	-1.095	-0.684	<.001	<.001	3	7
OV	ITGA4 →	-0.808	-0.417	.001	.001	3	7
OV	CALD1 →	-1.078	-0.414	<.001	<.001	3	7
UCEC	GMFG →	-0.941	-0.447	<.001	<.001	3	7
OV	VIM →	-1.085	-0.541	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,858 associations by consensus.

AFG3L2 vs NCF4 — UCEC

Explore this scatter interactively →