AFG3L2

Across TCGA patient cohorts, AFG3L2 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AFG3L2-associated genes across cancer lineages are Akt_pT308, ASNS, and ATM. Each is linked with AFG3L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AFG3L2-to-partner and partner-to-AFG3L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by AFG3L2-low versus AFG3L2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFG3L2→partner) and Y-score (partner→AFG3L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.443	+1.362	.046	.037	3	2
UCEC	ASNS →	+0.388	+1.906	.002	.015	3	2
UCEC	ATM →	-0.402	-1.362	.012	.037	3	2
UCEC	C-Raf →	+0.131	+2.321	.009	.005	3	2
UCEC	Cyclin-E1 →	+0.326	+1.362	.034	.037	3	2
LUSC	MYH11 →	-1.421	-2.990	.003	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Akt_pT308 by AFG3L2 expression — UCEC

Explore this box plot interactively →