AFG3L2

Across TCGA cell cohorts, AFG3L2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,565 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible AFG3L2-associated GO terms across cancer lineages are Regulation of mitochondrial DNA replication, RNA (guanine-N7)-methylation, and Mitotic nuclear division. Each is linked with AFG3L2 in more than 16 cancer types. Because this analysis shows association rather than direction, both AFG3L2-to-partner and partner-to-AFG3L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitochondrial DNA replication grouped by AFG3L2-low versus AFG3L2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AFG3L2→partner) and Y-score (partner→AFG3L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of mitochondrial DNA replication →	+0.120	+0.911	.004	.006	3	17
BONE	RNA (guanine-N7)-methylation →	+0.145	+0.921	<.001	<.001	3	17
BONE	Mitotic nuclear division →	+0.103	+0.655	.008	.003	3	14
BONE	Regulation of centrosome cycle →	+0.101	+0.758	.003	.003	3	13
LIVER	Mitochondrial protein quality control →	+0.238	+0.826	<.001	.001	3	13
BONE	Establishment of spindle localization →	+0.101	+1.014	.009	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,565 associations by consensus.

Regulation of mitochondrial DNA replication by AFG3L2 expression — LIVER

Explore this box plot interactively →