AFG3L2

Across TCGA cell cohorts, AFG3L2 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AFG3L2-associated genes across cancer lineages are CGB2, KNCN, and TACR3. Each is linked with AFG3L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AFG3L2-to-partner and partner-to-AFG3L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CGB2 grouped by AFG3L2-low versus AFG3L2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFG3L2→partner) and Y-score (partner→AFG3L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CGB2 →	+0.700	+3.234	<.001	.008	3	1
BLOOD_Leukemia	KNCN →	+0.024	+3.691	<.001	.002	3	1
BLOOD_Leukemia	TACR3 →	+0.030	+3.475	<.001	.006	3	1
BLOOD_Leukemia	VWC2L →	+0.009	+3.339	<.001	.006	3	1
BLOOD_Leukemia	PRM3 →	+0.045	+4.569	<.001	.003	3	1
BLOOD_Leukemia	DEFB125 →	+0.032	+3.475	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

CGB2 by AFG3L2 expression — BLOOD_Leukemia

Explore this box plot interactively →