AFG3L2

Across TCGA cell cohorts, AFG3L2 mutation is significantly associated with the mutation status of many other genes, with 4,037 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AFG3L2-associated genes across cancer lineages are GTSE1, COL5A3, and LZTR1. Each is linked with AFG3L2 in more than 2 cancer types. Because this analysis shows association rather than direction, both AFG3L2-to-partner and partner-to-AFG3L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GTSE1 grouped by AFG3L2-low versus AFG3L2-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFG3L2→partner) and Y-score (partner→AFG3L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GTSE1 →	+5.297	+5.297	.004	.004	1	3
BREAST	COL5A3 →	+4.297	+4.857	.009	.009	1	3
BREAST	LZTR1 →	+5.297	+5.297	.004	.004	1	3
BREAST	SPAG16 →	+5.297	+5.297	.004	.004	1	3
BREAST	TOR1AIP2 →	+5.297	+5.297	.004	.004	1	3
BREAST	PRPF8 →	+4.297	+4.857	.009	.009	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,037 associations by consensus.

GTSE1 by AFG3L2 expression — BREAST

Explore this box plot interactively →